Receptor-Binding and Oncogenic Properties of Polyoma Viruses Isolated from Feral Mice
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چکیده
منابع مشابه
Receptor-Binding and Oncogenic Properties of Polyoma Viruses Isolated from Feral Mice
Laboratory strains of the mouse polyoma virus differ markedly in their abilities to replicate and induce tumors in newborn mice. Major determinants of pathogenicity lie in the sialic binding pocket of the major capsid protein Vp1 and dictate receptor-binding properties of the virus. Substitutions at two sites in Vp1 define three prototype strains, which vary greatly in pathogenicity. These stra...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2007
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.0030179